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Pubblicazioni

Laboratorio di Chimica Bioorganica

 Falorni, M.; Porcheddu, A.; Giacomelli, G.
"Synthesis of (2R, 5S)- and (2S, 5S)-2-Carboxy-1,4-diaza-[4.3.0]bicyclononane as Building Blocks for the Synthesis of New Potential HIV Protease Inhibitors". Tetrahedron: Asymmetry, 1996, 7, 1999.

Falorni, M.; Porcheddu, A.; Giacomelli, G.
"General Approach to the Synthesis of Optically Active 2-Carboxy-4-[3'-(diethoxyphospinyl)propyl]-5-alkylpiperazines (CPP analogues)". Tetrahedron: Asymmetry, 1997, 8,  1633.

Falorni, M.; Giacomelli, G.; Mameli, L.; Porcheddu, A..
"New 1,3,5-triazine Derivatives as Templates for the Homogeneous Phase Synthesis of Chemical Libraries". Tetrahedron Lett., 1998, 39, 7607.

Falorni, M.;  Porcheddu, A.; Giacomelli, G..
"Natural α-Amino Acids as Starting Materials for Heterocycles Synthesis". Recent Res. Devel. in Synth. Organic Chem., 1998, 1, 225.

Falorni, M.; Giacomelli, G.; Porcheddu, A.; Taddei, M.
"A Simple Method for the Reduction of Carboxylic Acids to Aldehydes or Alcohols Using H2 and Pd/C" J. Org. Chem., 1999, 64, 8962.

 De Luca L.; Falorni, M.; Giacomelli, G.; Porcheddu, A.
"New pyrazole containing bicarboxylic α-amino acids: mimics of the cis amide bond"
Tetrahedron Lett., 1999, 40, 8701.

Falchi A..; Giacomelli, G.; Porcheddu, A.; Taddei, M.
"4-(4,6-Dimethoxy[1,3,5]triazin-2-yl)-4-methyl-morpholinium Chloride (DMTMM): a Valuable Alternative to PyBOP for Solid Phase Peptide Synthesis" Synlett, 2000, 275.

Falorni, M.; Giacomelli, G.; Porcheddu, A.; Taddei, M.
"Solution-Phase Synthesis of Mixed Amide Libraries by Simultaneous Addition of Functionalities (SPSAF) to a Diketopiperazine Tetracarboxylic Acid Scaffold Monitored by GC Analysis of Isobutyl Alcohol" Eur. J. Org. Chem., 2000, 1669.

De Luca L.; Giacomelli, G.; Porcheddu, A.; Spanedda, A. M.; Falorni, M.
"Synthesis of optically active α-aminoacids containing pyrazolyl ring as substituent"
Synthesis, 2000, 1295.

Falorni, M.; Giacomelli, G.; Porcheddu, A.; Dettori, G..
"New Oxazole Based Conformationally Restricted Peptidomimetics: Design and Synthesis of Pseudopetides" Eur. J. Org. Chem. 2000, 3217.

 De Luca L.; Giacomelli, G.; Porcu, G.; Taddei M.
"A New Supported Reagent for the Photochemical Generation of Radicals in Solution"
Org. Lett. 2001, 3, 855.

De Luca, L.; Giacomelli, G.; Taddei, M
"An Easy and Convenient Synthesis of Weinreb Amides and Hydroxamates" J. Org. Chem. 2001, 66, 2534.

De Luca L.; Giacomelli, G.; Porcheddu, A.
"A Simple Preparation of Ketones. N-Protected α-Amino Ketones from α-Amino Acids"
Org. Lett. 2001, 3, 1519.

De Luca L.; Giacomelli, G.; Porcheddu, A.
"A Very Mild and Chemoselective Oxidation of Alcohols to Carbonyl Compounds"
Org. Lett. 2001, 3, 3041.

De Luca, L.; Giacomelli, G.; Riu, A.
"Solid-phase Synthesis of Isoxazole-based Amino Acids: a New Scaffold for Molecular Diversity" J. Org. Chem. 2001, 66, 3041.

De Luca L.; Giacomelli, G.; Porcheddu, A.
"A Mild and Efficient Alternative to the Classical Swern Oxidation" J. Org. Chem.. 2001, 66, 7907.

De Luca L.; Giacomelli, G.; Porcheddu, A.
"An efficient Route to Alkyl Chloride from Alcohols Using the Complex TCT/DMF"
Org. Lett. 2002, 4, 553.

De Luca L.; Giacomelli, G.; Porcheddu, A.
"Mild and Highly Selective Formyl Protection of Primary Hydroxyl Groups" J. Org. Chem. 2002, 67, 5152.

De Luca L.; Giacomelli, G.; Porcheddu, A.
"Beckmann rearrangement of Oximes under Very Mild Conditions" J. Org. Chem. 2002, 67, 6272.

Giacomelli, G; Porcheddu, A.; Salaris, M.; Taddei, M.
“Microwave-Assisted Solution-Phase Synthesis of 1,4,5-Trisubstituted Pyrazoles,”
Eur. J. Org. Chem. 2003, 537.


De Luca L.; Giacomelli, G.; Masala, S.; Porcheddu, A.
"Trichloroisocyanuric/TEMPO Oxidation of Alcohols under Mild Conditions: A Close Investigation" J. Org. Chem. 2003, 68, 4999.

Giacomelli, G.; De Luca, L.; Porcheddu, A.
"A method for generating nitrile oxides from nitroalkanes: a microwave assisted route for isoxazoles" Tetrahedron 2003, 59, 5437.

De Luca L.; Giacomelli, G.; Porcheddu, A.; Salaris, M.; Taddei, M.
"Cellulose Beads: a New Versatile Solid Support for Microwave-Assisted Synthesis. Preparation of Pyrazole and Isoxazole Libraries" J. Comb. Chem. 2003, 4, 465.

De Luca L.; Giacomelli, G.; Porcheddu, A.; Salaris, M.; Taddei, M.
"Preparation of Pyrazole and Isoxazole Libraries on Cellulosa Bead: a New Cheap and Versatile Biopolymer" C. R. Chimie, 2003, 6, 607.

Giacomelli, G.; Porcheddu, A.; Salaris, M:
"A simple One-Flask Method for the Preparation of Hydroxamic Acids" Org. Lett. 2003, 5, 2715.

De Luca L.; Giacomelli, G.; Porcheddu, A.; Ruda, A. M.
" A “Catch and Release” Strategy for the Parallel Synthesis of 2,4,5-Trisubstituted Pyrimidines " J. Comb. Chem. 2004, 5,  105.

Porcheddu, A.; Giacomelli, G.
" Critical Survey Covering the Year 2003: Solid-Phase Synthesis "
in Seminars in Organic Sythesis, XXIX Summer School “A. Corbella” SCI ed: 2004, 705.

Giacomelli, G.; Porcheddu, A.; De Luca L.
" [1,3,5]-Triazine: A Versatile Heterocycle in Current Applications of Organic Chemistry " Current Organic Chemistry 2004, 8, 1497.

De Luca L.; Giacomelli, G.
" An Insight of the Reactions of Amines with Trichloroisocyanuric acid." Synlett 2004, 2180.

De Luca L.; Giacomelli, G.; Masala, S.; Porcheddu, A.
" A Mild Procedure for the Preparation of 3-Aryl-4-formylpyrazoles " Synlett 2004, 2299.

De Luca L.; Giacomelli, G.; Porcheddu, A.; Salaris, M.
" A New, Simple Procedure for the Synthesis of Formyl Amides " Synlett 2004, 2570.

Porcheddu, A.; Giacomelli, G.; Chighine, A.; Masala, M.
“New Cellulose-Supported Reagent: a Sustainable Approach to Guanidines” Org. Lett. 2004, 6, 4925.

De Luca L.; Giacomelli, G.; Nieddu, G.
" A Simple Protocol Efficient N-Chlorination of Amides and Carbamides " Synlett 2005, 223.

Porcheddu, A.; Giacomelli, G.; Salaris, M.
" Microwave Assisted Synthesis of Isonitriles: A General Simple Methodology " J. Org. Chem. 2005, 70, 2361.

Porcheddu, A.; Giacomelli, G.
" Peptide Nucleic Acids (PNAs), a chemical overview " Current Medicinal Chemistry 2005, 12, 2561.

De Luca, L.; Giacomelli, G.; Porcheddu, A.
" Synthesis of 1-Alkyl-4-imidazolecarboxylates: A Catch and Release Strategy "
J. Comb. Chem. 2005, 7,  905.

Porcheddu, A.; Giacomelli, G.
" Angeli-Rimini’s Reaction on Solid Support: A New Approach to Hydroxamic Acids"
    J. Org. Chem. 2006, 71, 7057.

De Luca L.; Giacomelli, G.; Nieddu, G.
" A Facile Approach to the Synthesis of Chiral 2-Substituted Benzofurans "
    J. Org. Chem. 2007, 72,  3955.

Porcheddu, A.; Giacomelli, G.
"Oxidations in organic chemistry: new perspectives " in Seminars in Organic Synthesis, XXXII Summer School “A. Corbella” SCI ed: 2007, 47.

Giacomelli, G.; Porcheddu, A.; De Luca, L.
    “Recent approaches to the solid-phase synthesis of N- and O-heterocycles
    in Modern Approaches to the Synthesis of O- and N-Heterocycles, Kaufman,     T.S. and Larghi, E. L. Ed. 2007, 2, 1-31.

De Luca L.; Giacomelli, G.
    "An Easy and Convenient Synthesis of Sulfonamides directly from Sulfonic Acids"
    J. Org. Chem. 2008, 73, 3967.

De Luca L.; Giacomelli, G.; Nieddu, G.
    "Synthesis of Substituted Benzofurans via Microwave-Enhanced Catch & Release     Strategy"
    J. Comb. Chem. 2008, 10, 517-520. (IF = 3.154)

Giacomelli, G.; Porcheddu, A..
    "1,3,5 Triazines" in 1,3,5-Triazines. In Comprehensive Heterocyclic Chemistry III, AR     Katritzky, CA Ramsden, EFV Scriven and RJK Taylor, Eds.; Elsevier: Oxford, 2008;     Vol. 9, pp 197 - 290.
   
Porcheddu, A.; Giacomelli, G.; Piredda, I.; Carta, M.; Nieddu, G.
    "A Practical and Efficient Approach to PNA Monomers Compatible with Fmoc-    Mediated Solid-Phase Synthesis Protocols" Eur. J. Org. Chem. 2008, 34, 5786.

Porcheddu, A.; Giacomelli, G.
    "Synthesis of oximes and hydroxamic acids”. In The Chemistry of Hydroxylamines,     Oximes and Hydroxamic Acids – Patai series: The Chemistry of Functional Groups,     Rappoport, Zvi / Liebman, Joel F. eds.).; John Wiley & Sons, 2008; pp 163-232.

Nieddu, G.; De Luca L.; Giacomelli, G.;
    "A Chemoselective, Easy Bromination of (Hydroxymethyl)phenols" Synthesis 2008, 10, 3937.

De Luca, L.; Nieddu, G.; Porcheddu, A.; Giacomelli, G.
"Some Recent Approaches to the Synthesis of 2-Substituted Benzofurans"
Current Medicinal Chemistry 2009, 16, 1.

Porcheddu, A.; Giacomelli, G.; Piredda, I.
    "Parallel Synthesis of Trisubstituted Formamidines: A Facile and
    Versatile Procedure" J. Comb. Chem. 2009, 11, 126.