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Sandra Piras

ARTICOLI:

M.Loriga,G.Paglietti,S.Piras,F.Sparatore,V.Anania,M.P.Demontis,M.V.Varoni,M.C.Fattaccio :Synthesis and evaluation of gastroprotective and antiulcer activity of some 2- substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles.
Il Farmaco 47,287-304.1992

S.Piras,M.Loriga,G.Paglietti,F.Sparatore,M.P.Demontis,M.V.Varoni,M.C.Fattaccio,V.Anania :Sinthesis and evaluation of gastroproctetive activity of omeprazole related benzimidazole,imidazo[4,5-b]pyridine and quinoxaline 2-substituted derivatives.
il Farmaco 48,1249-1259,1993

P.Sanna,P.A.Sequi,S.Piras,G.Paglietti :Reaction of 5-aminobenzotriazoles with methyl propiolate. Formation of triazolo[4,5-f]quinolines and related compounds. Unusual products in the Michael addition reaction of 2-methyl-2H-5-aminobenzotriazole.
Heterocycles 41,n°11,1995

S.Piras,M.Loriga,G.Paglietti,M.P.Demontis,M.V.Varoni,M.C.Fattaccio,V.Anania :Quinoxaline chemistry.Part 6 Synthesis and evaluation of antiulcer and gastroproctetive activity of 2-[arylmethylmercapto-,arylmethylsulfinyl-,piperazinyl-3-R-substituted]quinoxalines.
Il Farmaco 51,569-577,1996

M.Loriga,S.Piras,P.Sanna,G.Paglietti :quinoxaline chemistry.Part 7. 2-[aminobenzoates]-and2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Sinthesis and evaluation of in vitro anticancer, anti- HIV and antifungal activity.
Il Farmaco 52,157-166,1997

Piras S.,Loriga M.,Paglietti G.:Quinoxaline chemistry.Part14.4-(2-Quinoxalylamino)-phenylacetates and 4-(2-Quinoxalylamino)-phenylacetyl-L-glutamates as analogues-homologues of classical antifolate agents.Synthesis and evaluation of in vitro anticancer activity.
Il Farmaco 57 (2002) 1-8

M.Loriga, S.Piras , G.Paglietti, M.P. Costi, A. Venturelli, Quinoxaline chemistry.Part 15. 4-(2-Quinoxalylmethylenimino)-benzoylglutamates and -benzoates, 4-(2-quinoxalylmethyl-N-methylamino)-benzoylglutamates as analogues of classical antifolate agents. Synthesis,elucidation of structures and in vitro evaluation of antifolate and anticancer activities. Il Farmaco 58 (2003) 51-61

S.Piras, M.Loriga, G.Paglietti, Quinoxaline Chemistry. Part 17. 4[3,6(7) disubstituted-2-quinoxalinyl-oxa]phenylacetate and phenylacetylglutamate analogues of methotrexate: Synthesis and evaluation of in vitro anticancer activity.
Il Farmaco, 59, (2004), 186-194

A. Carta, S. Piras, G. Boatto and G. Paglietti. 1H,6H-triazolo[4,5-e]benzotriazole-3-oxides and 5,5'-(Z)-diazene-1,2-diylbis(2-methyl-2H-1,2,3-benzotriazole) derived from chloronitrobenzotriazoles and hydrazine. Heterocycles, 65, 10, 2005, 2471-2481.

A. Carta, M. Loriga, S. Piras , G. Paglietti, P. La Colla, B. Busonera, G. Collu, R. Loddo Synthesis of variously substituted 3- phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines. Medicinal Chemistry, 2006, vol. 2, pp. 113-122.

S. Piras, M. Loriga, A. Carta, G. Paglietti, M.P. Costi.Novel 3-benzoyl-2-piperazinylquinoxaline derivatives as potential antitumor agents. Journal of Heterocyclic Chemistry, 2006, vol. 43, pp. 1-8.

A. Carta, S. Piras, G. Loriga and G. PagliettiChemistry, Biological properties and SAR analysis of quinoxalinones. , Mini-Reviews in Medicinal Chemistry, 2006, vol. 6, pp. 1179-1200.

A. Carta, G. Loriga, S. Piras, G. Paglietti, M. Ferrone, M. Fermeglia, S. Pricl, P. La Colla, B. Secci, G. Collu and R. Loddo.Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides. Medicinal Chemistry, 2006, vol. 2, pp. 577-589.

A. Carta, M. Loriga, S. Piras, G. Paglietti, S. Pricl, P. La Colla, G. Collu, M.T. Sanna and R. Loddo.Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)fenyl]alkyldicarboxamides. Medicinal Chemistry, 2007, vol. 3, pp. 520-532.

A. Cavazzuti, G. Paglietti, W.N. Hunter, F. Gamarro, S. Piras, M. Loriga, S. Alleca, P. Corona, K.McLuskey, L. Tulloch, F. Gibellini, S. Ferrari and M.P. Costi.Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development. PNAS, 2008, 5:105, 1448-53.

A. Carta, S. Piras, M. Palomba, D. Jabes, P. Molicotti and S. Zanetti. Anti-mycobacterial activity of quinolones. Triazoloquinolones a new class of potent anti mycobacterial agents. Anti-Infective Agents in Medicinal Chemistry, 2008, vol 7, pp 134-147.

A. Carta, S. Piras, G. Paglietti, S. Pricl, P. La Colla, B. Busonera and R. Loddo. 2(3)-aryl-thio(oxy)-methylquinoxaline derivatives: a new classo f P-Glycoprotein-mediated drug efflux inhibitors. Medicinal Chemistry, 2008, vol 4, pp 194-205.

P. Corona, S. Piras, M. Palomba and A. Carta. Synthesis of linear azolo and pyrido quinolines from quinoline derivatives.Mini-Reviews in Organic Chemistry, 2008, vol 5, pp 295-302.

A. Carta, A. Sias, S. Piras and G. Paglietti.Reaction of alkylation of biologically interesting triazolo[4,5-g]quinolines and triazolo[4,5-g]quinoline-1-oxides with electrophilic reagents. Heterocycles, 2008, vol 75, pp 2493-2505.

G. Marverti, A. Ligabue, G. Paglietti, P. Corona, S. Piras. Collateral sensivity to novel thymidilate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells. European Journal of Pharmacology, vol616, pp17-26.

A. Carta, S. Piras, Carta A., Pricl S., Piras S., Fermeglia M., LaColla P., Loddo R. Activity and molecular modeling of a new small molecule active against NNRTI-resistant HIV-1 mutants. European Journal of Medicinal Chemistry, 44 (2009) 5117-5122

LIBRI:

A. Carta, S. Piras, I.Briguglio,Manuale di Analisi Farmaceutica: analisi organica qualitativa non strumentale. Aracne editrice Roma 2009


ARTICOLI DI LIBRI:

Piras S.,Corona P., Carta A., Helicase inhibitors as anti-RNA virus agents. Chapter of " RNA-viruses. Enzymatic and Receptoral Inhibitors" 2009. Editor A.Carta.Managing Editor S.G. Pandalai. Published by Research Signpost, Kerala, India

PARTECIPAZIONI A CONGRESSI:

1. A. CARTA, G. VITALE, PIRAS S., P. CORONA, G. PAGLIETTI, S. PRICL, M. FERMEGLIA, P. LA COLLA, G. GILIBERTI, D. COLLU, R. LODDO. (2008). Quinoline triciclic derivatives. Design, synthesis and preliminary in vitro and in silico antiviral activity against flaviviridae family of three new classes of virus-encoded RNA-dependent RNA polymerase (RdRp) inhibitors. XIX National Meeting on Medicinal Chemistry. 14-18 settembre 2008.

2. M. PALOMBA, S. MURRU, P. CORONA, PIRAS S., A. CARTA. (2008). [1,2,3]triazolo[4,5-H]chinoloni: una nuova classe di promettenti chemioterapici antitubercolari. SardiniaChem 2008. 30-05-2008.

3. P. CORONA, A. SIAS, PIRAS S., M. PALOMBA, A. CARTA. (2008). 4,7-fenantroline: una nuova classe di inibitori della polimerasi di RNA-virus. SardiniaChem 2008. 30-05-2008.

4. PIRAS S., I. BRIGUGLIO, P. CORONA, M. PALOMBA, A. CARTA. (2008). E-3-aril-2-(1H-benzotriazol-1-il)acrilonitrili: una nuova classe di inibitori della tubulina ad attività antitumorale. SardiniaChem. 30-05-2008.

5. A.CARTA, M.PALOMBA, PIRAS S., A. SIAS, P. MOLICOTTI, S. CANNAS, S. ZANETTI. (2007). Triazolochinoloni. Una nuova classe di agenti antitubercolari attivi su ceppi MDR di M. tuberculosis. XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana. 16-20 settembre 2007.

6. A.CARTA, PIRAS S., M.PALOMBA, S. PRICL, P. LA COLLA, C. IBBA, R. LODDO. (2007). Benzotriazolilfenilalchilammidi. Una nuova classe di inibitori delle RNA elicasi di virus a singola catena a RNA a genoma positivo e negativo. XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana. 16-20 settembre 2007.

7. PIRAS S., M. LORIGA, G. PAGLIETTI, M.P. COSTI, S. FERRARI. (2007). Novel quinoxaline analogues as inhibitors of folate enzimes. Medicinal Chemistry in Parasitology: new avenues in drug discovery. 19-20 febbraio 2007.

8. A. CARTA, C.GIUA, PIRAS S., A.SIAS, G.LORIGA, G.PAGLIETTI. (2006). Sintesi di nuove 6,7- diamminochinoline quali intermedi per la preparazione di molecole ad attività biologica. SardiniaChem 2006. 5-06-2006.

9. A.CARTA, M.LORIGA, PIRAS S., B.SECCI, A.VISIOLI, P.LA COLLA. (2005). Synthesis and in vitro evaluation of the antiviral activity of a series of novel N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides. Second Joint Italian-Swiss meeting on medicinal chemistry. 12-16 settembre 2005. 12-16 settembre 2005.

10. A.CARTA, M.LORIGA, PIRAS S., P.LA COLLA, B. BUSONERA, R.LODDO. (2005). Synthesis and in vitro anticancer evaluatio of variously substituted 3- phenoxymethyl quinoxalin-2-ones and quinoxalines in combination with various drugs against kb mdr tumor cells. Second Joint Italian-Swiss meeting on medicinal chemistry. 12-16 settembre 2005.

11. PIRAS S., A.CARTA, M.LORIGA, MFNAEIAN, G.PAGLIETTI. (2004). Sintesi di una nuova serie di N-[4-(1H(2H)-benzotriazol-1(2)-il)fenil]alchilcarbossiammidi e N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-il)fenil]alchildicarbossiammidi a potenziale attività antivirale. SardiniaChem. 31-05-2004.

12. PIRAS S., M.LORIGA, G.PAGLIETTI, M.P.COSTI, S.FERRARI. (2004). nuovi derivari chinossalinici inibitori della diidrofolato reduttasi (DHFR) e della timidilato sintetasi (TS) della leishmania major: risultati preliminari. XVII Convegno Nazionale della divisione di Chimica Farmaceutica della Società Chimica Italiana. 6-10 settembre 2004.